UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

 

 

SCHEDULE 13G

 

Under the Securities Exchange Act of 1934

  (Amendment No. 1)*

 

 

 

Inozyme Pharma, Inc.

(Name of Issuer)

   

Common stock, $0.0001 par value per share

 

(Title of Class of Securities)

  

45790W108

 

(CUSIP Number)

  

December 31, 2021

 

(Date of Event Which Requires Filing of This Statement)

 

 

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

   Rule 13d-1(b)

   Rule 13d-1(c)

   Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act, but shall be subject to all other provisions of the Act (however, see the Notes).

 

 
 

CUSIP No.  45790W108

13G Page 2 of 17 Pages    

1  

NAMES OF REPORTING PERSON(S)

 

New Enterprise Associates 15, L.P.

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware limited partnership

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

PN

 

   

 
 

 

CUSIP No.  45790W108

13G Page 3 of 17 Pages    

 

1  

NAMES OF REPORTING PERSON(S)

 

NEA Partners 15, L.P.

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware limited partnership

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

PN

 

   

 
 

CUSIP No.  45790W108

13G Page 4 of 17 Pages    

 

1  

NAMES OF REPORTING PERSON(S)

 

NEA 15 GP, LLC

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware limited liability company

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

OO

 

   

 
 

CUSIP No.  45790W108

13G Page 5 of 17 Pages    

 

1  

NAMES OF REPORTING PERSON(S)

 

Forest Baskett

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

United States

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

IN

 

   

 
 

CUSIP No.  45790W108

13G Page 6 of 17 Pages    

 

1  

NAMES OF REPORTING PERSON(S)

 

Anthony A. Florence, Jr.

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

United States

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

IN

 

   

 

 

 

CUSIP No.  45790W108

13G Page 7 of 17 Pages    

 

1  

NAMES OF REPORTING PERSON(S)

 

Mohamad H. Makhzoumi

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

United States

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

IN

 

   

 
 

CUSIP No.  45790W108

13G Page 8 of 17 Pages    

 

1  

NAMES OF REPORTING PERSON(S)

 

Scott D. Sandell

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

United States

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

IN

 

   

 

 

CUSIP No.  45790W108

13G Page 9 of 17 Pages    

 

1  

NAMES OF REPORTING PERSON(S)

 

Peter W. Sonsini

 

   
2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 

 

 

 

(a)

(b)

3  

SEC USE ONLY

 

 

 

   
4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

United States

  

   
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
 

 5

 

SOLE VOTING POWER

 

0

 

  6  

SHARED VOTING POWER

 

2,437,689 shares

 

  7  

SOLE DISPOSITIVE POWER

 

0

 

  8  

SHARED DISPOSITIVE POWER

 

2,437,689 shares

 

9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

2,437,689 shares

 

   
10  

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

 

 

 

   
11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  

10.3%

 

   

 12

 

TYPE OF REPORTING PERSON

   

IN

 

   

 
 

CUSIP No.  45790W108

13G Page 10 of 17 Pages    

 

 

Item 1(a). Name of Issuer:

 

Inozyme Pharma, Inc. (the “Issuer”).

 

 

Item 1(b). Address of Issuer's Principal Executive Offices:

 

321 Summer Street, Suite 400, Boston, Massachusetts 02210.

 

 

Item 2(a). Names of Persons Filing:

 

This statement is being filed by New Enterprise Associates 15, L.P. (“NEA 15”); NEA Partners 15, L.P. (“NEA Partners 15”), which is the sole general partner of NEA 15; NEA 15 GP, LLC (“NEA 15 GP”), which is the sole general partner of NEA Partners 15; and Forest Baskett (“Baskett”), Anthony A. Florence, Jr. (“Florence”), Mohamad H. Makhzoumi (“Makhzoumi”), Scott D. Sandell (“Sandell”) and Peter W. Sonsini (“Sonsini”) (collectively, the “Managers”) and Joshua Makower (“Makower”). The Managers are the managers of NEA 15 GP. NEA 15, NEA Partners 15, NEA 15 GP and the Managers are sometimes referred to collectively herein as the “Reporting Persons”. 

 

 

Item 2(b). Address of Principal Business Office or, if none, Residence:

 

The address of the principal business office of NEA 15, NEA Partners 15, NEA 15 GP and Sandell is New Enterprise Associates, 1954 Greenspring Drive, Suite 600, Timonium, MD 21093. The address of the principal business office of Baskett, Makhzoumi, and Sonsini is New Enterprise Associates, 2855 Sand Hill Road, Menlo Park, California 94025. The address of the principal business office of Florence is New Enterprise Associates, 104 5th Avenue, 19th Floor, New York, NY 10001.

 

 

Item 2(c). Citizenship:

 

Each of NEA 15 and NEA Partners 15 is a Delaware limited partnership. NEA 15 GP is a Delaware limited liability company. Each of the Managers is a United States citizen.

 

 

Item 2(d). Title of Class of Securities.

 

Common stock, $0.0001 par value (“Common Stock”).

 

 

Item 2(e). CUSIP Number.

 

45790W108

 

  

Item 3. If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

 

Not Applicable.

 

 
 

CUSIP No.  45790W108

13G Page 11 of 17 Pages    

 

Item 4. Ownership:

 

  (a)

Amount Beneficially Owned: NEA 15 is the record owner of 2,437,689 shares of Common Stock as of December 31, 2021 (the “Shares”). As the sole general partner of NEA 15, NEA Partners 15 may be deemed to own beneficially the Shares. As the sole general partner of NEA Partners 15, NEA 15 GP likewise may be deemed to own beneficially the Shares. As the individual Managers of NEA 15 GP, each of the Managers also may be deemed to own beneficially the Shares.

 

  (b)

Percent of Class: See Line 11 of cover sheets. The percentages set forth on the cover sheet for each Reporting Person are calculated based on 23,664,747 shares of Common Stock reported by the Issuer to be outstanding as of November 8, 2021 on the Issuer’s Form 10-Q filed with the Securities and Exchange Commission on November 9, 2021.

     
  (c) Number of shares as to which such person has:

  (i)

Sole power to vote or to direct the vote:     See Line 5 of the cover sheets.

     
  (ii)

Shared power to vote or to direct the vote:    See Line 6 of the cover sheets.

     
  (iii)

Sole power to dispose or to direct the disposition of:      See Line 7 of the cover sheets.

     
  (iv)

Shared power to dispose or to direct the disposition of:     See Line 8 of the cover sheets.

     

Each Reporting Person disclaims beneficial ownership of such Securities except for the shares, if any, such Reporting Person holds of record.

 

 

Item 5. Ownership of Five Percent or Less of a Class.

Makower has ceased to own beneficially five percent or more of the Issuer’s Common Stock as a result of ceasing to be a Manager of NEA 15 GP.

 

 

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

 

Not applicable.

 

 

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

 

Not applicable.

 

 

Item 8. Identification and Classification of Members of the Group.

 

Not applicable. The Reporting Persons expressly disclaim membership in a “group” as used in Rule 13d-5(b).

 

 

Item 9. Notice of Dissolution of Group.

 

Not applicable.

 

 

Item 10. Certification.

 

Not applicable. This Schedule 13G is not filed pursuant to Rule 13d-1(b) or Rule 13d–1(c).

 

 

Material to be Filed as Exhibits.

 

Exhibit 1 – Agreement regarding filing of joint Schedule 13G.

 

Exhibit 2 – Power of Attorney regarding filings under the Securities Exchange Act of 1934, as amended.

 
 

CUSIP No.  45790W108

13G Page 12 of 17 Pages    

 

 

SIGNATURE

After reasonable inquiry and to the best of its knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.

 

EXECUTED this 7th day of February, 2022.

 

 

NEW ENTERPRISE ASSOCIATES 15, L.P.

 

By:NEA PARTNERS 15, L.P.
General Partner

 

By:NEA 15 GP, LLC
General Partner

 

By:                       *                      

  Louis S. Citron

  Chief Legal Officer

 

 

 

NEA PARTNERS 15, L.P.

 

By:NEA 15 GP, LLC
General Partner

 

By:                        *                      

 Louis S. Citron

 Chief Legal Officer

 

 

  

NEA 15 GP, LLC

 

By:                        *                      

 Louis S. Citron

 Chief Legal Officer

 

 

 

                              *                       

Forest Baskett

 

 

                              *                        

Anthony A. Florence, Jr.

 

 

                              *                       

Mohamad H. Makhzoumi

 

 

                              *                       

Joshua Makower

 

 

 

 

 

 

CUSIP No.  45790W108

13G Page 13 of 17 Pages    

  

 

 

 

 

                              *                       

Scott D. Sandell

 

 

                              *                       

Peter W. Sonsini

 

 

 

*/s/ Louis S. Citron             

Louis S. Citron

As attorney-in-fact

 

This Amendment No. 1 to Schedule 13G was executed by Louis S. Citron on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which is attached as Exhibit 2.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
 

CUSIP No.  45790W108

13G Page 14 of 17 Pages    

 

 

Exhibit 1

 

AGREEMENT

 

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of stock of Inozyme Pharma, Inc.

 

EXECUTED this 7th day of February, 2022.

 

 

NEW ENTERPRISE ASSOCIATES 15, L.P.

 

By:NEA PARTNERS 15, L.P.
General Partner

 

By:NEA 15 GP, LLC
General Partner

 

By:                       *                      

  Louis S. Citron

  Chief Legal Officer

 

 

 

NEA PARTNERS 15, L.P.

 

By:NEA 15 GP, LLC
General Partner

 

By:                        *                      

 Louis S. Citron

 Chief Legal Officer

 

 

  

NEA 15 GP, LLC

 

By:                        *                      

 Louis S. Citron

 Chief Legal Officer

 

 

 

                              *                       

Forest Baskett

 

 

                              *                        

Anthony A. Florence, Jr.

 

 

                              *                       

Mohamad H. Makhzoumi

 

 

                              *                       

Joshua Makower

 

 

 

 

 

 

 

CUSIP No.  45790W108

13G Page 15 of 17 Pages    

 

 

 

 

                              *                       

Scott D. Sandell

 

 

                              *                       

Peter W. Sonsini

 

 

 

*/s/ Louis S. Citron             

Louis S. Citron

As attorney-in-fact

 

This Agreement was executed by Louis S. Citron on behalf of the individuals listed above pursuant to a Power of Attorney a copy of which is attached as Exhibit 2.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
 

CUSIP No.  45790W108

13G Page 16 of 17 Pages    

Exhibit 2

 

POWER OF ATTORNEY

 

KNOW ALL MEN BY THESE PRESENTS, that the undersigned hereby constitutes and appoints Louis S. Citron, Timothy Schaller, Sasha Keough and Stephanie Brecher, and each of them, with full power to act without the others, his or her true and lawful attorney-in-fact, with full power of substitution, to sign any and all instruments, certificates and documents that may be necessary, desirable or appropriate to be executed on behalf of himself as an individual or in his or her capacity as a direct or indirect general partner, director, officer or manager of any partnership, corporation or limited liability company, pursuant to section 13 or 16 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any and all regulations promulgated thereunder, and to file the same, with all exhibits thereto, and any other documents in connection therewith, with the Securities and Exchange Commission, and with any other entity when and if such is mandated by the Exchange Act or by the Financial Industry Regulatory Authority, granting unto said attorney-in-fact full power and authority to do and perform each and every act and thing necessary, desirable or appropriate, fully to all intents and purposes as he or she might or could do in person, thereby ratifying and confirming all that said attorney-in-fact, or his or her substitutes, may lawfully do or cause to be done by virtue hereof.

 

IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 13th day of March, 2017.

 

 

/s/ M. James Barrett                    

M. James Barrett

 

/s/ Peter J. Barris                          

Peter J. Barris

 

/s/ Forest Baskett                         

Forest Baskett

 

/s/ Ali Behbahani                         

Ali Behbahani

 

/s/ Colin Bryant                            

Colin Bryant

 

/s/ Carmen Chang                        

Carmen Chang

 

/s/ Anthony A. Florence, Jr.      

Anthony A. Florence, Jr.

 

/s/ Carol G. Gallagher                  

Carol G. Gallagher

 

/s/ Dayna Grayson                       

Dayna Grayson

 

/s/ Patrick J. Kerins                      

Patrick J. Kerins

 

 

 

 

 

 

 

 

 

  

CUSIP No.  45790W108

13G Page 17 of 17 Pages    

 

 

 

/s/ P. Justin Klein                         

P. Justin Klein

 

/s/ Vanessa Larco                        

Vanessa Larco

 

/s/ Joshua Makower                    

Joshua Makower

 

/s/ Mohamad H. Makhzoumi    

Mohamad H. Makhzoumi

 

/s/ Edward T. Mathers                

Edward T. Mathers

 

/s/ David M. Mott                        

David M. Mott

 

/s/ Sara M. Nayeem                     

Sara M. Nayeem

 

/s/ Jason R. Nunn                        

Jason R. Nunn

 

/s/ Gregory Papadopoulos         

Gregory Papadopoulos

 

/s/ Chetan Puttagunta                 

Chetan Puttagunta

 

/s/ Jon Sakoda                              

Jon Sakoda

 

/s/ Scott D. Sandell                      

Scott D. Sandell

 

/s/ A. Brooke Seawell                 

A. Brooke Seawell

 

/s/ Peter W. Sonsini                     

Peter W. Sonsini

 

/s/ Melissa Taunton                    

Melissa Taunton

 

/s/ Frank M. Torti                        

Frank M. Torti

 

/s/ Ravi Viswanathan                  

Ravi Viswanathan

 

/s/ Paul E. Walker                         

Paul E. Walker

 

/s/ Rick Yang                                

Rick Yang